RECOMBINANT C1 INHIBITOR IN THE PREVENTION OF SEVERE COVID-19: A RANDOMIZED, OPEN-LABEL, MULTI-CENTER PHASE IIA TRIAL

Recombinant C1 inhibitor in the prevention of severe COVID-19: a randomized, open-label, multi-center phase IIa trial

BackgroundConestat alfa (ConA), a recombinant human C1 inhibitor, may prevent thromboinflammation.MethodsWe conducted a randomized, open-label, multi-national clinical trial in which hospitalized adults at risk for progression to severe COVID-19 were assigned in a 2:1 ratio to receive either 3 days of ConA plus standard of care (SOC) or SOC alone.P

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Pseudomonas aeruginosa two-component system LadS/PA0034 regulates macrophage phagocytosis via fimbrial protein cupA1

ABSTRACT Pseudomonas aeruginosa is one of the most common nosocomial pathogens worldwide, known for its virulence, drug resistance, and elaborate sensor-response network.The primary challenge encountered by pathogens during the initial stages of infection is the immune clearance arising from the host.The resident macrophages of barrier organs serve

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Quantifying the Matrix Metalloproteinase 2 (MMP2) Spatially in Tissues by Probe via MALDI Imaging Mass Spectrometry

As a matrix metalloproteinase, the abnormal expression of MMP2 is associated with multiple biological processes, including tissue remodeling and cancer progression.Therefore, spatial analysis of MMP2 protein in tissues can be used as an Insulated Beverage Server Lids important approach to evaluate the expression distribution of MMP2 in complex tiss

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